Announcement PDF ASX Announcement UPDATED TOP 20 OPTION HOLDERS LIST Melbourne, Australia – 6 November 2026: Percheron Therapeutics Limited (ASX: PER) ('the Company'), an international biotechnology company focused on developing novel therapies for oncology, provides an updated Top 20 Option holders list to reflect revised registry records regarding the total number of Options on issue. This version replaces the previously released list. ~ ENDS ~ About Percheron Therapeutics Limited Percheron Therapeutics Limited [ASX: PER | US OTC: PERCF] is a publicly listed biotechnology company focused on the development and commercialisation of novel therapies for oncology. The company’s lead program is HMBD-002, a monoclonal antibody targeting the immune checkpoint regulator, VISTA. HMBD-002 has completed a phase 1 clinical trial in patients with advanced cancer, showing the drug is generally safe and well tolerated, and Percheron aims to commence further clinical trials in CY2026. For more information, please contact info@PercheronTx.com. This announcement has been authorised for release to the Australian Securities Exchange by the Percheron Board of Directors Page | 1 Boardroom Pty Limited Level 8, 210 George Street Sydney NSW 2000 ABN 14 003 209 836 GPO Box 3993 Sydney NSW 2001 Tel: 1300 737 760 (within Aust) Tel: + 61 2 9290 9600 (outside Aust) Fax: + 61 2 9279 0664 www.boardroomlimited.com.au enquiries@boardroomlimited.com.au Top 20 Holdings Percheron Therapeutics Limited 6 November 2026 Securities class - Listed Opt Exp15 Apr 2028 @$0.01 Name/Address 1 Name/Address 2 Name/Address 3 Options $0.01 Expiring 15 April 2028 L39 Pty Ltd <No 12 A/C> 77,500,000 Mr Richard John Mann 30,779,461 Kea Holdings Pty Ltd <10S Holding A/C> 25,000,000 1215 Capital Pty Ltd 25,000,000 Deck Chair Holdings Pty Ltd 25,000,000 HSBC Custody Nominees (Australia) Limited 15,600,000 Kea Holdings Pty Ltd <Ios Holding A/C> 15,000,000 Deck Chair Holdings Pty Ltd 15,000,000 Deck Chair Holdings Pty Ltd 15,000,000 Non Correlated Capital Pty Ltd <Investius PB Micro Cap A/C> 14,000,000 Kea Holdings Pty Ltd <Ios Holding A/C> 13,395,238 Mann Beef Pty Ltd 11,220,539 Dr James Stuart Garner 10,700,000 Dmmy Holdings Pty Ltd <Dmmy Investment A/C> 10,000,000 Riya Investments Pty Ltd 9,250,000 Allekian Exchange Pty Ltd 9,250,000 Alcanterra Group Pty Ltd 8,000,000 Major Holdings Pty Ltd 8,000,000 Mutual Investments Pty Ltd <Mitchell Family A/C> 7,078,796 Mrs Carolyn A Bernardi & Mr Pierre Ralph Bernardi <Carolyn Bernardi Super F A/C> 6,000,000 Top 20 Holders 350,774,034 Total on Issue 574,987,505